The Microsoft Exchange Server computer is not available. Unable to open your default e-mail folders. When you start Microsoft Office Outlook by using a profile that includes a mailbox on a server that's running Microsoft Exchange Server 2010, Exchange Server 2013, or Exchange Server 2016, you may receive the following error messages:Ĭannot start Microsoft Office Outlook. The article only applies to the Microsoft Outlook connection issues that are caused by the RPC encryption requirement.
Outlook connection issues with Exchange mailboxes caused by the RPC encryption requirement